7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-
ML-030
CAS: 1013750-77-0
Molecular Formula: C20H20N4O4S
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)- - Names and Identifiers
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)- - Physico-chemical Properties
| Molecular Formula | C20H20N4O4S |
| Molar Mass | 412.46 |
| Melting Point | >182°C (dec.) |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Off-White to Pale Yellow |
| Storage Condition | -20°C Freezer |
| In vitro study | ML-030 is potent in cell-based assay with an EC 50 value of 18.7 nM. |
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.424 ml | 12.122 ml | 24.245 ml |
| 5 mM | 0.485 ml | 2.424 ml | 4.849 ml |
| 10 mM | 0.242 ml | 1.212 ml | 2.424 ml |
| 5 mM | 0.048 ml | 0.242 ml | 0.485 ml |
Last Update：2024-01-02 23:10:35
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)- - Reference Information
| biological activity | ML-030 is a potent PDE4 inhibitor for PDE4A,PDE4A1,PDE4B1,PDE4B2, the IC50 values for PDE4C1 and PDE4D2 are 6.7 nM,12.9 nM,48.2 nM,37.2 nM,452 nM and 49.2 nM, respectively. |
| Target | IC50: 6.7 nM (PDE4A), 12.9 nM (PDE4A1), 48.2 nM (PDE4B1), 37.2 (PDE4B2) nM, 452 (PDE4C1) nM, 49.2 (PDE4D2) nM |
Last Update：2024-04-09 15:16:56
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CAS: 1013750-77-0
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CAS: 1013750-77-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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